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在“Elsevier电子期刊”中，命中：2,305条，耗时：0.2359126 秒

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1.Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus

作者：Hyun Lee^a ; Jinhong Ren^b ; Salvatore Nocadello^d ; Amy J. Rice^b ; ^c ; Isabel Ojeda^b ; ^c ; Samuel Light^d ; George Minasov^d ; Jason Vargas^b ; ^c ; Dhanapalan Nagarathnam^e ; Wayne F. Anderson^d ; Michael E. Johnson^a ; ^{mssjohnson@novalextherapeutics.com}

关键词：Zika flavivirus ; NS2B/NS3 serine protease ; Small molecule inhibitor ; apo ZIKV NS2B-NS3pro structure

刊名：Antiviral Research

出版年：2017

2.Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes

作者：Christine M. Burrer^a ; ¹ ; Helen Auburn^a ; ¹ ; Xu Wang^b ; Juntao Luo^b ; Fardokht A. Abulwerdi^c ; Zaneta Nikolovska-Coleska^c ; Gary C. Chan^a ; ^{chang@upstate.edu}

关键词：Cytomegalovirus ; Monocytes ; Myeloid cell leukemia 1 ; Nanoparticles ; Small-molecule inhibitor

刊名：Antiviral Research

出版年：2017

3.An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors

作者：Weiyan Cheng^a ; Mixiang Wang^b ; Xin Tian^a ; ^{tianx@zzu.edu.cn} ; Xiaojian Zhang^a ; ^{firstpha@163.com}

关键词：FGFR ; Small molecule inhibitor ; Crystal structure ; DFG-in/out ; Irreversible ; Pharmacological activity

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Strong synergism between small molecule inhibitors of HER2, PI3K, mTOR and Bcl-2 in human breast cancer cells

作者：Roswita H. Hamunyela ; MTech^a ; ^b ; ^{hamunyela.rh@gmail.com} ; Antonio M. Serafin ; Ph.D.^a ; ^ts@sun.ac.za ; John M. Akudugu ; Ph.D.^a ; ^{jakudugu@sun.ac.za}

关键词：Small molecule inhibitor ; Synergism ; Triple-negative cancer

刊名：Toxicology in Vitro

出版年：2017

5.Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

作者：Xia Li¹ ; Xing-Xing Fan¹ ; Ze-Bo Jiang ; Wings TY Loo ; Xiao-Jun Yao ; Elaine Lai-Han Leung ; ^{lhleung@must.edu.mo} ; Louis WC Chow ; ^{wcchow@must.edu.mo} ; Liang Liu ; ^{lliu@must.edu.mo}

关键词：NSCLC ; non-small cell lung cancer cell ; ROS ; reactive oxygen species ; EGFR ; epidermal growth factor receptor ; T790M ; a substitution mutation of threonine with methionine at position 790 of EGFR ; TrxR ; thioredoxin reductases ; MTT ; 3-(4 ; 5-dimetrylthiazol)-2 ; 5-diphenyltetrazolium bromide ; DCFDA ; dichlorofluorescein diacetate ; PBS ; phosphate-buffered saline ; RIPA ; radioimmunoprecipitation assay ; PARP ; poly (ADP-ribosyl) polymerase ; NAC ; N-acetyl-l-cysteine ; MG132 ; proteasomal degradation pathway inh

刊名：Pharmacological Research

出版年：2017

6.Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells

作者：Jeanne G. Quirit^a ; ^{jgquirit@berkeley.edu} ; Sergey N. Lavrenov^b ; ^{satory@mail.ru} ; Kevin Poindexter^a ; ^{kpoindexter25@gmail.com} ; Janice Xu^a ; ^{jamicexu@scripps.edu} ; Christine Kyauk^a ; ^{ckyauk@berkeley.edu} ; Kathleen A. Durkin^c ; ^{durkin@berkeley.edu} ; Ida Aronchik^a ; ^{idaaronchik@gmail.com} ; Thomas Tomasiak^d ; ^{tomasiak@msg.ucsf.edu} ; Yaroslav A. Solomatin^b ; ^{hercules44@yandex.ru} ; Maria N. Preobrazhenskaya^b ; ^{satory@mail.ru} ; Gary L. Firestone^a ; ^{glfire@berkeley.edu}

关键词：Indole-3-carbinol analogues ; Ligand-target protein interactions ; NEDD4-1 ubiquitin ligase ; In silico computational modeling ; Anti-cancer compounds ; Melanoma cells

刊名：Biochemical Pharmacology

出版年：2017

7.Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer

作者：Shabir Ahmad Ganai ^{Shabir.muntazir82@gmail.com}

关键词：Apigenin ; HATs ; HDACs ; HDACi ; Prostate cancer ; Flavonoid

刊名：Biomedicine & Pharmacotherapy

出版年：2017

8.EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance

作者：Shuhang Wang^a ; Yongping Song^b ; Delong Liu^b ; ^{delong_liu@nymc.edu}

关键词：EGFR ; EAI045 ; TKI ; AZD9291 ; Rociletinib

刊名：Cancer Letters

出版年：2017

9.Synergistic effects of negatively charged hydrophobic nanoparticles and (−)-epigallocatechin-3-gallate on inhibiting amyloid β-protein aggregation

作者：Hongchen Liu ; Linling Yu ; Xiaoyan Dong ; Yan Sun ; ^{ysun@tju.edu.cn}

关键词：Polymeric nanoparticle ; (&minus ; )-Epigallocatechin-3-gallate ; Amyloid β-protein ; Aggregation ; Inhibition

刊名：Journal of Colloid and Interface Science

出版年：2017

10.Double probe approach to protein adsorption on porous carbon surfaces

作者：Balá ; zs Nagy^a ; Ajna Tó ; th^a ; Irina Savina^b ; Sergey Mikhalovsky^b ; Lyuba Mikhalovska^b ; Erik Geissler^c ; Krisztina Lá ; szló ; ^a ; ^{klaszlo@mail.bme.hu}

关键词：Adsorption ; Protein ; BSA ; BPTI ; Carbon aerogel ; Porosity ; Surface chemistry

刊名：Carbon

出版年：2017

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