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Wiley电子期刊(3)	SpringerLink电子期刊(18)	Elsevier电子期刊(193)
Springer电子图书(1)	NATURE电子期刊(1)	ACS电子期刊(18)

在“Elsevier电子期刊”中，命中：193条，耗时：0.0189902 秒

在所有数据库中总计命中：234条

1.A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models

作者：Yayoi Kawata^a ; ^{yayoi.kawata@takeda.com} ; Shoki Okuda^a ; Natsu Hotta^a ; Hideyuki Igawa^a ; Masashi Takahashi^a ; Minoru Ikoma^a ; Shizuo Kasai^a ; Ayumi Ando^a ; Yoshinori Satomi^a ; Mayumi Nishida^a ; Masaharu Nakayama^a ; Syunsuke Yamamoto^a ; Yasutaka Nagisa^a ; ¹ ; Shiro Takekawa^a

关键词：Melanin-concentrating hormone 1 receptor antagonist ; Obesity ; Non-alcoholic fatty liver disease

刊名：European Journal of Pharmacology

出版年：2017

2.Nesfatin-1 regulates the lateral hypothalamic area melanin-concentrating hormone-responsive gastric distension-sensitive neurons and gastric function via arcuate nucleus innervation

作者：Luo Xu^a ; ^{xu.luo@163.com} ; Hongbo Wang^b ; Yanling Gong^c ; Mingjie Pang^d ; Xiangrong Sun^a ; Feifei Guo^a ; Shengli Gao^a

关键词：Nesfatin-1 ; Melanin-concentrating hormone ; Gastric distension neurons ; Gastric secretion ; Lateral hypothalamic area

刊名：Metabolism

出版年：2017

3.Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test

作者：Hideyuki Igawa^a ; ^{hideyuki.igawa@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Masashi Takahashi^a ; Minoru Ikoma^a ; Hiromi Kaku^a ; Keiko Kakegawa^a ; Asato Kina^a ; Jumpei Aida^a ; Shoki Okuda^a ; Yayoi Kawata^a ; Toshihiro Noguchi^a ; Natsu Hotta^a ; Syunsuke Yamamoto^a ; Masaharu Nakayama^a ; Yasutaka Nagisa^b ; Shizuo Kasai^a ; Tsuyoshi Maekawa^a

关键词：MCHR1 antagonist ; MCH ; Antiobesity agent ; Indazole ; Ames test ; Mutagenicity ; DNA intercalator

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.Evolution of physicochemical properties of melanin concentrating hormone receptor 1 (MCHr1) antagonists

作者：Anders Johansson ^{anders.m.johansson@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Melanin concentrating hormone receptor 1 ; MCHr1 ; CNS ; Target engagement ; Physicochemical properties

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition

作者：Hideyuki Igawa^a ; ^{hideyuki.igawa@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Masashi Takahashi^a ; Mikio Shirasaki^a ; Keiko Kakegawa^a ; Asato Kina^a ; Minoru Ikoma^a ; Jumpei Aida^a ; Tsuneo Yasuma^b ; Shoki Okuda^a ; Yayoi Kawata^a ; Toshihiro Noguchi^a ; Syunsuke Yamamoto^a ; Yasushi Fujioka^a ; Mrinalkanti Kundu^c ; Uttam Khamrai^c ; Masaharu Nakayama^a ; Yasutaka Nagisa^d ; Shizuo Kasai^a ; Tsuyoshi Maekawa^a

关键词：MCH ; melanin-concentrating hormone ; MCHR1 ; melanin-concentrating hormone receptor 1 ; CYP3A4 ; cytochrome P450 3A4 ; TDI ; time-dependent inhibition ; DIO ; diet-induced obesity ; hERG ; human ether-a-go-go related gene ; DMEDA ; N ; N&prime ; -dimethylethylenediamine ; HATU ; (1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate) ; DIPEA ; N ; N-diisopropylethylamine ; TFAA ; trifluoroacetic anhydride ; ADDP ; 1 ; 1&prime ; -(azodicarbonyl)dipiperidine ; MW ; microwave ; CHO ; Chinese

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

作者：Pratik Devasthale^a ; ^{pratik.devasthale@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Wang^a ; James Mignone^a ; Kishore Renduchintala^b ; Sridhar Radhakrishnan^b ; Jayanthi Dhanapal^b ; Jagannath Selvaraj^b ; Rajesh Kuppusamy^b ; Mary Ann Pelleymounter^c ; Daniel Longhi^c ; Ning Huang^c ; Neil Flynn^c ; Anthony V. Azzara^c ; Kenneth Rohrbach^c ; James Devenny^c ; Suzanne Rooney^c ; Michael Thomas^c ; Susan Glick^c ; Helen Godonis^c ; Susan Harvey^c ; Mary Jane Cullen^c ; Hongwei Zhang^d ; Christian Caporuscio^d ; Paul Stetsko^c ; Mary Grubb^c ; Christine Huang^c ; Lisa Zhang^c ; Chris Freeden^c ; Brian J. Murphy^c ; Jeffrey A. Robl^a ; William N. Washburn^a ;

关键词：Non-basic MCHR1 antagonists ; Anti-obesity ; Off-rates ; Biliary toxicity ; Metabolite toxicity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

7.Inactivation of the melanin concentrating hormone system impairs maternal behavior

作者：Amal Alachkar^a ; ^{aalachka@uci.edu" class="auth_mail" title="E-mail the corresponding author} ; Lamees Alhassen^a ; Zhiwei Wang^a ; Lien Wang^a ; Kara Onouye^a ; Nayna Sanathara^a ; Olivier Civelli^a ; ^b ; ^c

关键词：Melanin concentrating hormone ; Maternal behavior ; Knockout ; Mice ; Antagonist

刊名：European Neuropsychopharmacology

出版年：2016

8.Comparison of Adherence to Rivaroxaban Versus Apixaban Among Patients With Atrial Fibrillation

作者：Colleen A. McHorney ; MD¹ ; Eric D. Peterson ; MD ; MPH ; FAHA ; FACC² ; Franç ; ois Laliberté ; MA³ ; Guillaume Germain ; MA³ ; ^{guillaume.germain@analysisgroup.com" class="auth_mail" title="E-mail the corresponding author} ; Winnie W. Nelson ; MS ; MBA⁴ ; Concetta Crivera ; MPH⁴ ; Jeffrey Schein ; PhD⁴ ; Patrick Lefebvre ; MA³

关键词：adherence ; anticoagulant ; apixaban ; atrial fibrillation ; rivaroxaban

刊名：Clinical Therapeutics

出版年：2016

9.Two fungal endophytes reduce the severity of pitch canker disease in Pinus radiata seedlings

作者：Pablo Martí ; nez-Á ; lvarez^a ; ^b ; ^{pmtnez@pvs.uva.es" class="auth_mail" title="E-mail the corresponding author} ; Raú ; l Arcadio Ferná ; ndez-Gonzá ; lez^a ; ^b ; Antonio Vicente Sanz-Ros^a ; ^b ; ^c ; Valentí ; n Pando^a ; ^d ; Julio Javier Diez^a ; ^b

关键词：Fusarium circinatum ; Field test ; Inoculation ; Dual cultures ; Biological control agents

刊名：Biological Control

出版年：2016

10.Mechanism of NMDA Receptor Inhibition and Activation

作者：Shujia Zhu¹ ; Richard A. Stein² ; Craig Yoshioka³ ; Chia-Hsueh Lee¹ ; ⁵ ; April Goehring¹ ; Hassane S. Mchaourab² ; Eric Gouaux¹ ; ⁴ ; ^{gouauxe@ohsu.edu" class="auth_mail" title="E-mail the corresponding author}

刊名：Cell

出版年：2016

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