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Wiley电子期刊(10)	SpringerLink电子期刊(503)	Elsevier电子期刊(1798)
Springer电子图书(2)	NATURE电子期刊(16)	ACS电子期刊(170)

在“Elsevier电子期刊”中，命中：1,798条，耗时：0.0819545 秒

在所有数据库中总计命中：2,499条

1.Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B

作者：Marko Jukič^a ; Janez Ila&scaron ; ^a ; Matjaž Brvar^b ; Danijel Kikelj^a ; Jožko Cesar^a ; Marko Anderluh^a ; ^{marko.anderluh@ffa.uni-lj.si}

关键词：Antibiotics ; Antibacterials ; Inhibitor ; DNA gyrase B ; ATP binding site ; Pyrrole-2-carboxamides ; Structure-based drug design ; Ligand-based drug design

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

作者：Xin Luo¹ ; ² ; ³ ; ⁸ ; Keun Woo Ryu¹ ; ² ; ³ ; ⁸ ; Dae-Seok Kim¹ ; ² ; Tulip Nandu¹ ; ² ; Carlos J. Medina⁴ ; Rebecca Gupte¹ ; ² ; Bryan A. Gibson¹ ; ² ; ⁵ ; Raymond E. Soccio⁴ ; Yonghao Yu⁶ ; Rana K. Gupta⁷ ; W. Lee Kraus¹ ; ² ; ³ ; ⁹ ; ^{lee.kraus@utsouthwestern.edu}

关键词：adipogenesis ; C/EBPβ ; DNA binding ; gene expression ; PARP inhibitor ; PARP-1 ; PARylation ; poly(ADP-ribose) ; transcription

刊名：Molecular Cell

出版年：2017

3.Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

作者：Tihomir Toma&scaron ; ič^a ; ^{tihomir.tomasic@ffa.uni-lj.si} ; Matic Mirt^a ; Michaela Barančoková ; ^a ; Janez Ila&scaron ; ^a ; Nace Zidar^a ; Pä ; ivi Tammela^b ; Danijel Kikelj^a

关键词：Antibacterial ; DNA gyrase ; Docking ; Inhibitor ; Thiazole

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

4.Reversal of platinum drug resistance by the histone deacetylase inhibitor belinostat

作者：Kenneth Kin-Wah To^a ; ^{kennethto@cuhk.edu.hk} ; Wing-Sum Tong^a ; Li-wu Fu^b

关键词：ABC ; ATP-binding cassette ; CFDA ; carboxy-2&rsquo ; 7&rsquo ; -dichlorofluorescein diacetate ; MDR ; multidrug resistance ; NC2 ; negative cofactor 2 ; NSCLC ; non-small cell lung cancer ; Pt ; platinum ; SRB ; sulforhodamine B

刊名：Lung Cancer

出版年：2017

5.Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor

作者：Kulrawee Sidthipong^a ; Jun Ma^b ; Wei Lin Yu^b ; Yan Feng Wang^b ; Susumu Kobayashi^c ; Satoshi Kishino^d ; Naoki Koide^e ; Takashi Yokochi^e ; Kuniki Kato^a ; Shoshiro Okada^f ; Kazuo Umezawa^a ; ^{umezawa@aichi-med-u.ac.jp}

关键词：(&minus ; )-DHMEQ ; Cysteine ; NF-κB ; α-Exomethylene-γ-lactone ; Bioconjugate

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.13-Ethylberberine reduces HMGB1 release through AMPK activation in LPS-activated RAW264.7 cells and protects endotoxemic mice from organ damage

作者：Dong Ung Lee^c ; ¹ ; Young Shin Ko^a ; ¹ ; Hye Jung Kim^a ; ^b ; Ki Churl Chang^a ; ^b ; ^{kcchang@gnu.kr}

关键词：BBR ; berberine ; CLP ; cecal ligation and puncture ; HMGB1 ; high mobility group box 1 ; HO-1 ; heme oxygenase-1 ; iNOS ; inducible nitric oxide synthase ; LPS ; lipopolysaccharide ; NF-κB ; Nuclear factor kappa B ; NO ; nitric oxide ; siRNA ; small interfering RNA ; H&E ; hematoxylin and eosin ; PCNA ; proliferating cell nuclear antigen ; DMEM ; dulbecco&rsquo ; s modified eagle&rsquo ; s medium ; FBS ; fatal bovine serum ; AMPK ; AMP-activated protein kinase ; 13-EBR ; 13-ethylberberine ; TNF-α ; tumor necrosis factor-alpha ; I

刊名：Biomedicine & Pharmacotherapy

出版年：2017

7.Recent progress in the development of protein-protein interaction inhibitors targeting androgen receptor-coactivator binding in prostate cancer

作者：Eric Biron^a ; ^b ; ^{eric.biron@pha.ulaval.ca" class="auth_mail" title="E-mail the corresponding author} ; Franç ; ois Bé ; dard^a ; ^b

关键词：AB ; Sandrogen-binding site ; AF ; activation function ; AR ; androgen receptor ; ARA ; androgen receptor-associated protein ; ARE ; androgen-responsive elements ; BF3 ; binding function 3 ; CBI ; coactivator binding inhibitor ; CBP ; CREB-binding protein ; CPRC ; castration-resistant prostate cancer ; CYP ; cytochrome P450 ; DBD ; DNA-binding domain ; DHT ; 5α-dihydrotestosterone ; ER ; estrogen receptor ; FP ; fluorescence polarization ; GRIP1 ; glutamate receptor interacting protein 1 ; LBD ; ligand-binding domain ; NLS ; n

刊名：Journal of Steroid Biochemistry and Molecular Biology

出版年：2016

8.Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft

作者：Bradley R. Kossmann^a ; Monica Abdelmalak^b ; Sophia Lopez^b ; Gabrielle Tender^b ; Chunli Yan^a ; Yves Pommier^b ; Christophe Marchand^b ; ^{marchanc@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author} ; Ivaylo Ivanov^a ; ^{iivanov@gsu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Tyrosyl-DNA phosphodiesterase 2 ; TDP2 ; Inhibitor ; Virtual screening ; Rational drug design

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor

作者：Masaomi Terajima ; ^{masaomi.terajima@astellas.com" class="auth_mail" title="E-mail the corresponding author} ; Yoko Kaneko-Kobayashi ; Naoto Nakamura ; Masatoshi Yuri ; Masashi Hiramoto ; Masanori Naitou ; Kazuyuki Hattori ; Hiroyuki Yokota ; Hidekazu Mizuhara ; Yasuyuki Higashi

关键词：AIA ; adjuvant-induced arthritis ; DC ; dendritic cell ; DMF ; N ; N-dimethylformamide ; IRF ; interferon regulatory factor ; MALDI-TOFMS ; MALDI-TOF mass spectrometry ; MDP ; muramyldipeptide ; PI ; phosphoinositide ; Poly(I ; C) ; polyinosinic-polycytidylic acid ; TNP ; 24 ; 6-trinitrophenol

刊名：European Journal of Pharmacology

出版年：2016

10.Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors

作者：Wei Zhang^a ; ^b ; ^c ; Bin Zhang^c ; Wei Zhang^b ; ^c ; Ti Yang^a ; Ning Wang^a ; ^b ; Chunmei Gao^a ; ^b ; ^{chunmeigao@sz.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Chunyan Tan^b ; ^d ; Hongxia Liu^b ; Yuyang Jiang^a ; ^b ; ^d ; ^{jiangyy@sz.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Acridine derivatives ; Topoisomerase II inhibitor ; Antiproliferative activity ; DNA damage

刊名：European Journal of Medicinal Chemistry

出版年：2016

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