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在“Elsevier电子期刊”中，命中：782条，耗时：0.046978 秒

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1.S - and N-alkylating agents diminish the fluorescence of fluorescent dye-stained DNA

作者：Robert Giesche^a ; Harald John^a ; Kai Kehe^b ; ^c ; Annette Schmidt^a ; Tanja Popp^a ; ^b ; Frank Balzuweit^e ; ^d ; Horst Thiermann^a ; Thomas Gudermann^b ; ^e ; Dirk Steinritz^a ; ^b ; ^{dirksteinritz@bundeswehr.org}

关键词：Chemical warfare agents ; DNA staining ; Sulfur mustard ; Fluorescent dyes ; Mass spectrometry ; Ethidium bromide

刊名：Chemico-Biological Interactions

出版年：2017

2.Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients

作者：Andrea Sartore-Bianchi^a ; Filippo Pietrantonio^b ; Alessio Amatu^a ; Massimo Milione^c ; Andrea Cassingena^a ; Silvia Ghezzi^a ; Marta Caporale^b ; Rosa Berenato^b ; Chiara Falcomatà ; ^d ; ^e ; Alessio Pellegrinelli^c ; Alberto Bardelli^d ; ^e ; Michele Nichelatti^a ; Federica Tosi^a ; Filippo De Braud^b ; Federica Di Nicolantonio^d ; ^e ; Ludovic Barault^d ; ^e ; ¹ ; ^{ludovic.barault@unito.it} ; Salvatore Siena^a ; ^f ; ¹

关键词：MGMT ; Immunohistochemistry ; DNA methylation ; Digital PCR ; Metastatic colorectal cancer ; Alkylating agent

刊名：European Journal of Cancer

出版年：2017

3.The use of molecular dynamics simulations to evaluate the DNA sequence-selectivity of G-A cross-linking PBD-duocarmycin dimers

作者：Paul J.M. Jackson ; Khondaker M. Rahman ; David E. Thurston

关键词：DNA cross-linking ; Pyrrolobenzodiazepine ; Duocarmycin ; PBD&ndash ; CPI dimer ; Molecular dynamics ; PBD ; CPI ; CBI ; Seco-amino CI

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs

作者：Songwen Lin¹ ; Yingbo Li¹ ; Yufen Zheng ; Laichun Luo ; Qi Sun ; ^{sunqi@bjmu.edu.cn} ; Zemei Ge ; Tieming Cheng ; Runtao Li ; ^{lirt@bjmu.edu.cn}

关键词：Multi-target-directed ligands ; Anticancer drugs ; EGFR/HER2 inhibitors ; DNA alkylating agents ; Phosphoramide mustard

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

作者：Joanna Klapacz^a ; ^{jklapacz@dow.com" class="auth_mail" title="E-mail the corresponding author} ; Lynn H. Pottenger^a ; ^b ; Bevin P. Engelward^c ; Christopher D. Heinen^d ; George E. Johnson^e ; Rebecca A. Clewell^f ; Paul L. Carmichael^g ; Yeyejide Adeleye^g ; Melvin E. Andersen^f

关键词：AAG ; alkyladenine DNA glycosylase ; ATM ; ataxia telangiectasia mutated ; BER ; base excision repair ; BPD ; break point dose ; BMD ; benchmark dose ; BMDL ; benchmark dose lower confidence limit ; CSBP ; computational systems biology pathway ; DSB ; double strand breaks ; DDR ; DNA damage response ; DRCs ; DNA repair centers ; EMS ; ethylmethanesulfonate ; ENU ; ethylnitrosourea ; FYDR ; fluorescent yellow direct repeat ; HR ; homologous repair ; MGMT ; methylguanine methyl transferase ; MMS ; methylmethane sulfonate ; MNNG

刊名：Mutation Research/Reviews in Mutation Research

出版年：2016

6.Synthesis and biological activity of benzamide DNA minor groove binders

作者：Gul Shahzada Khan^a ; ^b ; Lisa I. Pilkington^b ; David Barker^b ; ^{d.barker@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author}

关键词：DNA binding agents ; Minor groove binders ; Benzamides ; Anti-proliferative ; DNA melting analysis

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.DNA cleavage at the AP site via β-elimination mediated by the AP site-binding ligands

作者：Yukiko S. Abe ; Shigeki Sasaki ; ^{sasaki@phar.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：AP site repair ; β-Elimination ; Binding ligand ; DNA cleavage ; APE1

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.Analogues of DNA minor groove cross-linking agents incorporating aminoCBI, an amino derivative of the duocarmycins: Synthesis, cytotoxicity, and potential as payloads for antibody-drug conjugates

作者：Anna C. Giddens^a ; Ho H. Lee^a ; Guo-Liang Lu^a ; Christian K. Miller^a ; Jun Guo^b ; Gail D. Lewis Phillips^b ; Thomas H. Pillow^b ; Moana Tercel^a ; ^{m.tercel@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author}

关键词：ADC ; antibody&ndash ; drug conjugate ; BINAP ; 2 ; 2&prime ; -bis(diphenylphosphino)-1 ; 1&prime ; -binaphthalene ; CBI ; 129 ; 9a-tetrahydrocyclopropa[c]benz[e]indol-4-one ; EDCI ; N-ethyl-N&prime ; -(3-dimethylaminopropyl)carbodiimide hydrochloride ; MMAE ; monomethyl auristatin E ; PBD ; pyrrolobenzodiazepine ; Pgp ; P-glycoprotein

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Ovarian cancer: Status of homologous recombination pathway as a predictor of drug response

作者：Nicolas De Picciotto^aAuthor Vitae ; Wulfran Cacheux^a ; Arnaud Roth^a ; Pierre O. Chappuis^a ; ^b ; S. Intidhar Labidi-Galy^a ; ^{intidhar.labidi-galy@hcuge.ch" class="auth_mail" title="E-mail the corresponding author}Author Vitae

关键词：Ovarian cancer ; BRCAness ; Homologous recombination ; Platinum ; PARP inhibitor ; Alkylating agents ; HRness ; BRCA mutation

刊名：Critical Reviews in Oncology and Hematology

出版年：2016

10.The possible role of intravenous lipid emulsion in the treatment of chemical warfare agent poisoning

作者：Arik Eisenkraft^a ; ^b ; ^c ; ^{aizenkra@netvision.net.il} ; Avshalom Falk^a ; ^{nbc_pd@mod.gov.il}

关键词：Intravenous lipid emulsion ; Organophosphates ; Sulfur mustard ; Antidotes ; Poisoning ; Chemical Warfare agents

刊名：Toxicology Reports

出版年：2016

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