作者：Aishwarya Balap^a ; Sathiyanarayanan Lohidasan^a ; Arulmozhi Sinnathambi^b ; Kakasaheb Mahadik^a ; ^{krmahadik@redifffmail.com}

关键词：AN ; Andrographolide ; ANOVA ; Analysis of variance ; APE ; Andrographis paniculata Nees Extract ; AUC 0-&infin ; Area under plasma concentration-time curve extrapolated to infinity ; AUC0&minust ; Area under plasma concentration-time curve from zero to last time point ; AUMC0-&infin ; Area under the concentration time (c&times ; t) versus time (t) curve for extrapolated to infinity ; AUMC0&minust ; Area under the concentration time (c&times ; t) versus time (t) curve for last time point ; CL ; Plasma clearanc

刊名：Journal of Ethnopharmacology

出版年：2017

作者：Takahiko Saida^a ; ^{saida_takahiko@maia.eonet.ne.jp} ; Jun-ichi Kira^b ; Shuji Kishida^c ; Takashi Yamamura^d ; Yukiko Sudo^e ; Kazutaka Ogiwara^e ; JT Tibung^e ; Nisha Lucas^f ; Meena Subramanyam^f ; On behalf of Natalizumab Trial Principal Investigators

关键词：AE ; adverse event ; ARR ; annualized relapse rate ; AUC ; area under the concentration time curve ; AUC0&ndash ; last ; area under the curve to the last measurable concentration of a dosing interval ; AUC0&ndash ; &infin ; area under the curve to infinity ; AUC0&ndash ; 672 ; area under the curve for dosing interval ; CI ; confidence interval ; CL ; systemic clearance ; Cmax ; maximum concentration ; Ctrough ; trough concentration ; EDSS ; Expanded Disability Status Scale ; ELISA ; enzyme-linked immunosorbent assay ; Gd ; g

刊名：Multiple Sclerosis and Related Disorders

出版年：2017

作者：Kareem AbuBakr Soliman ; ^{karim.mohamed@pharma.cu.edu.eg} ; Howida Kamal Ibrahim ; Mahmoud Mohammed Ghorab

关键词：ANOVA ; analysis of variance ; AUC(0&minus ; &infin) ; area under plasma concentration-time curve extrapolated to infinity ; Cmax ; peak plasma concentration ; D.E.(0&ndash ; 30) ; dissolution efficiency (0&ndash ; 30&thinsp ; min) ; DMSO ; dimethyl sulphoxide ; DSC ; differential scanning calorimetry ; FDA ; United States Food and Drug Administration ; HPH ; high pressure homogenization ; HLB ; hydrophilic-lipophilic balance ; HPLC ; high-performance liquid chromatography ; PDE5 ; phosphodiesterase enzyme type 5 ; PDI ; pol

刊名：International Journal of Pharmaceutics

出版年：2017

作者：Jiseon Kim^a ; Jee Sun Min^a ; Doyun Kim^a ; Yu Fen Zheng^a ; Karabasappa Mailar^b ; Won Jun Choi^b ; Choongho Lee^b ; Soo Kyung Bae^a ; ^{baesk@catholic.ac.kr} ; ^{espero97@hanmail.net}

关键词：AUC0-t ; total area under the plasma concentration&minus ; time curve from time zero to time t ; AUC0-&infin ; total area under the plasma concentration&minus ; time curve from time zero to time infinity ; F ; bioavailability ; Cl ; total plasma clearance ; Cmax ; peak plasma concentration ; IS ; internal standard ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; LLOQ ; lower limit of quantitation ; QC ; quality control ; RE ; relative error ; RSD ; relative standard deviation ; Vd ; steady-state

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2017

作者：Jaime R. Bastian ; PharmD^a ; ^d ; ^{jbas22@gmail.com} ; Huijun Chen^d ; Hongfei Zhang ; MSc^d ; Scott Rothenberger ; PhD^b ; Ralph Tarter ; PhD^d ; Dennis English ; MD^a ; Raman Venkataramanan ; PhD^c ; ^d ; Steve N. Caritis ; MD^a

关键词：buprenorphine ; exposure ; pharmacokinetics ; plasma concentration ; pregnancy

刊名：American Journal of Obstetrics and Gynecology

出版年：2017

作者：Yoshiki Kojo ; Saori Matsunaga ; Hiroki Suzuki ; Hideyuki Sato ; Yoshiki Seto ; Satomi Onoue ; ^{onoue@u-shizuoka-ken.ac.jp}

关键词：ADI ; acceptable daily intake ; AUC ; area under the curve of blood concentration vs. time ; DLS ; dynamic light scattering ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; DSC ; differential scanning calorimetry ; GI ; gastrointestinal ; IEC6 cell ; intestinal epithelioid cell line No.6 derived from neonatal rat ileum ; ITZ ; itraconazole ; LD50 ; lethal dose 50% ; LDH ; lactate dehydrogenase ; NaPB ; sodium phosphate buffer ; PLM ; polarized light microscopy ; PXRD ; powder X-ray diffraction ; RH

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Alison Margolskee^a ; ^{alison.margolskee@manchester.ac.uk} ; Adam S. Darwich^a ; Xavier Pepin^b ; ^c ; Leon Aarons^a ; Aleksandra Galetin^a ; Amin Rostami-Hodjegan^a ; ^d ; Sara Carlert^e ; Maria Hammarberg^e ; Constanze Hilgendorf^e ; Pernilla Johansson^e ; Eva Karlsson^e ; Dó ; nal Murphy^b ; Christer Tannergren^e ; Helena Thö ; rn^e ; Mohammed Yasin^b ; Florent Mazuir^c ; Olivier Nicolas^c ; Sergej Ramusovic^f ; Christine Xu^g ; Shriram M. Pathak^d ; Timo Korjamo^h ; Johanna Laru^b ; ^h ; Jussi Malkki^h ; Sari Pappinen^h ; Johanna Tuunainen^h ; Jennifer Dressmanⁱ ; Simone Hansmannⁱ ; Edmund Kostewiczⁱ ; Handan He^j ; Tycho Heimbach^j ; Fan Wu^j ; Carolin Hoft^k ; Loic Laplanche^k ; Yan Pang^k ; Michael B. Bolger^l ; Eva Huehn^l ; Viera Lukacova^l ; James M. Mullin^l ; Ke X. Szeto^l ; Chester Costales^m ; Jian Lin^m ; Mark McAllisterⁿ ; Sweta Modi^m ; Charles Rotter^m ; Manthena Varmaⁿ ; Mei Wongⁿ ; Amitava Mitra^o ; Jan Bevernage^p ; Jeike Biewenga^p ; Achiel Van Peer^p

关键词：API ; Active pharmaceutical ingredient ; AUC ; Area under the curve ; BCS ; Biopharmaceutics classification system ; BE ; Bioequivalence ; BP ; Blood-to-plasma ratio ; CL ; Clearance ; CL/F ; Apparent clearance ; Cmax ; Maximum concentration ; Do ; Dose number ; fa ; Fraction absorbed ; FIM ; First in man ; Foral ; Absolute oral bioavailability ; Frel ; Relative bioavailability ; fup ; Fraction unbound in plasma ; IMI ; Innovative Medicines Initiative ; i.v. ; Intravenous ; IR ; Immediate release ; LogP ; Logarithm of the octanol

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Hiroki Suzuki^a ; Kodai Ueno^a ; Takahiro Mizumoto^b ; Yoshiki Seto^a ; Hideyuki Sato^a ; Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp}

关键词：AUC ; area under the curve of blood concentration versus time curve ; BALF ; bronchoalveolar lavage fluid ; BUN ; blood urea nitrogen ; Cmax ; maximum concentration ; CsA ; cyclosporine A ; CsA-RP ; amorphous cyclosporine A-based respirable powder ; FPD ; fine particle dose ; FPF ; fine particle fraction ; HPMC ; hydroxypropyl methylcellulose ; MPO ; myeloperoxidase ; OVA ; ovalbumin ; OVA-RP ; ovalbumin-based respirable powder ; PBS ; phosphate buffer solution ; RP ; respirable powder ; SMSD/CsA-RP ; self-micellizing solid

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Hiroki Suzuki^a ; Shun Hamao^a ; Yoshiki Seto^a ; Hideyuki Sato^a ; Jennifer Wong^b ; Robert K. Prud&rsquo ; homme^c ; Hak-Kim Chan^b ; ^{kim.chan@sydney.edu.au} ; Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp}

关键词：AUC ; area under the curve of blood concentration versus time curve ; BA ; bioavailability ; BCS ; biopharmaceutics classification system ; Cmax ; maximum concentration ; CsA ; cyclosporine A ; CV ; coefficient of variation ; DLS ; dynamic light scattering ; FNP ; flash nano precipitation ; MIVM ; multi-inlet vortex mixer ; NP ; nanoparticle ; nCsA ; nanoprecipitated cyclosporine A powder ; nCsA/MAN ; nano-matrix formulation of nanoprecipitated cyclosporine A using mannitol ; SEM ; scanning electron microscopic ; tmax ; t

刊名：International Journal of Pharmaceutics

出版年：2017

作者：Hao Dun^a ; Lijun Song^a ; Anlun Ma^a ; Yanxin Hu^a ; Lin Zeng^b ; Jieying Bai^b ; Guangzhou Zhang^b ; Liangyan Zhang^b ; Kumi Koide^c ; Yohei Okada^c ; Kaori Hanaoka^c ; Rie Yamamoto^c ; Jun Hirose^c ; Tatsuaki Morokata^c ; Pierre Daloze^a ; Huifang Chen^a ; ^{hui.fang.chen@umontreal.ca}

关键词：AUC(0&ndash ; 24) ; the area under the plasma concentration-time curves from 0 to 24 h ; Cmax ; the maximum plasma concentration ; CNI ; calcineurin inhibitor ; MS ; multiple sclerosis ; MST ; median survival time ; NHPs ; nonhuman primates ; PD ; pharmacodynamic ; PK ; pharmacokinetic ; QD ; once daily ; S1P ; sphingosine-1-phosphate ; SCr ; serum creatinine ; SLOs ; secondary lymphoid organs ; Tmax ; the time to reach Cmax

刊名：Transplant Immunology

出版年：2017