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Elsevier电子期刊(197)

在“Elsevier电子期刊”中，命中：197条，耗时：0.0959546 秒

在所有数据库中总计命中：309条

1.Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates

作者：Taeko Kubo ; DVM ; PhD^a ; ^b ; ^c ; ^{taeko-kubo@ds-pharma.co.jp} ; ^{taekok2016@gmail.com} ; Takashi Ashihara ; MD ; PhD^b ; Tadashi Tsubouchi ; PhD^a ; Minoru Horie ; MD ; PhD^b

关键词：AP ; action potential ; APD ; action potential duration ; APD30 ; APD at 30% repolarization ; APD90 ; APD at 90% repolarization ; APD30&ndash ; 90 ; APD90&ndash ; APD30 ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CiPA ; Comprehensive in vitro Proarrhythmia Assay ; CV ; conduction velocity ; EAD ; early afterdepolarization ; ECG ; electrocardiogram ; Endo ; endocardial ; Epi ; epicardial ; FH ; failing heart ; ICH ; International Conference of Harmonization ; IQ-CSRC ; Innovation and Quality in Pharmaceutical Deve

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial

作者：Rosa-M. Valls^a ; ¹ ; Marta Farrà ; s^b ; ^c ; ¹ ; Anna Pedret^a ; ¹ ; Sara Ferná ; ndez-Castillejo^a ; Ú ; rsula Catalá ; n^a ; Marta Romeu^e ; Montse Giralt^e ; Guillermo-T. Sá ; ez^f ; Montserrat Fitó ; ^b ; Rafael de la Torre^g ; Marí ; a-Isabel Covas^b ; Marí ; a-José ; Motilva^d ; ^{motilva@tecal.udl.es} ; Rosa Solà ; ^a ; ^{rosa.sola@urv.cat} ; Laura Rubió ; ^a ; ^d

关键词：FVOO ; functional virgin olive oil ; GPx ; glutathione peroxidase ; HPLC ; high performance liquid chromatography ; hsCRP ; high sensitivity C-reactive protein ; ICAM-1 ; intercellular cell adhesion molecule ; ICH GPC ; international conference of harmonization ; IRH ; ischemic reactive hyperemia ; MCP-1 ; monocyte chemotactic protein ; NOx ; nitric oxide ; PAI-1 ; plasminogen activator inhibitor type I ; PC ; phenolic compounds ; TG ; triglycerides ; UPLC-MS/MS ; ultra performance liquid chromatography-mass spectrometr

刊名：Journal of Functional Foods

出版年：2017

3.Robustness testing in the determination of seven drugs in animal muscle by liquid chromatography-tandem mass spectrometry

作者：M.L. Oca^a ; L. Rubio^a ; M.C. Ortiz^a ; ^{mcortiz@ubu.es" class="auth_mail" title="E-mail the corresponding author} ; L.A. Sarabia^b ; I. Garcí ; a^c

关键词：ICH ; International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use ; IUPAC ; International Union of Pure and Applied Chemistry ; LC/MS&ndash ; MS ; Liquid chromatography coupled to tandem mass spectrometry ; XYL ; Xylazine ; AZA ; Azaperone ; PROP ; Propionylpromazine ; CHLOR ; Chlorpromazine ; HALO ; Haloperidol ; AZOL ; Azaperol ; CAR ; Carazolol ; SPE ; Solid-phase extraction ; MRL ; Maximum residue limit ; IS ; Internal standard ; APCI ; Atmospheric pressure chemi

刊名：Chemometrics and Intelligent Laboratory Systems

出版年：2016

4.Comparative study on prediction performance of photosafety testing tools on photoallergens

作者：Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Hiroto Ohtake^a ; Gen Suzuki^a ; Yoshiki Seto^a ; Hayato Nishida^b ; Morihiko Hirota^b ; Takao Ashikaga^b ; Hirokazu Kouzuki^b

关键词：3T3 NRU PT ; 3T3 neutral red uptake phototoxicity testing ; AOP ; Adverse Outcome Pathway ; DMSO ; dimethyl sulfoxide ; ICH ; International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use ; IFRA ; International Fragrance Association ; JaCVAM ; Japanese Center for the Validation of Alternative Methods ; JPMA ; Japan Pharmaceutical Manufacturers Association ; MEC ; molar extinction coefficient ; mROS assay ; micellar ROS assay ; NaPB ; sodium phosphate buffer

刊名：Toxicology in Vitro

出版年：2016

5.Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development

作者：Alavattam Sreedhara^a ; ^{sreedhaa@gene.com" class="auth_mail" title="E-mail the corresponding author} ; Jian Yin^b ; Michael Joyce^a ; Kimberly Lau^a ; Aaron T. Wecksler^c ; Galahad Deperalta^c ; Li Yi^a ; Y. John Wang^a ; Bruce Kabakoff^b ; Ravuri S.K. Kishore^d

关键词：ACN ; acetonitrile ; DTT ; dithiothreitol ; FS ; fluorescence ; His ; l-Histidine ; ICH ; International Conference on Harmonization ; mAb ; monoclonal antibody ; Met ; l-Methionine ; Phe ; Phenylalanine ; TFA ; trifluoroacetic acid ; Trp ; l-Tryptophan ; Tyr ; l-Tyrosine

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

6.Rational quality assessment procedure for less-investigated herbal medicines: Case of a Congolese antimalarial drug with an analytical report

作者：Dieudonné ; Tshitenge Tshitenge^a ; ^b ; Karine Ndjoko Ioset^a ; José ; Nzunzu Lami^b ; Josaphat Ndelo-di-Phanzu^b ; Jean-Pierre Koy Sita Mufusama^a ; ^b ; Gerhard Bringmann^a ; ^{bringman@chemie.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author}

关键词：INERA ; Institut National pour l'Etude et la Recherche Agronomiques ; HPLC ; high performance liquid chromatography ; DAD ; diode array detector ; CRS ; chemical reference substance ; ICH ; International Conference on Harmonization ; ANOVA ; analysis of variance ; SD ; standard deviation ; RSD ; repeatability standard deviation ; NMR ; nuclear magnetic resonance ; COSY ; correlation spectroscopy ; TOCSY ; total correlation spectroscopy ; HSQC ; heteronuclear single quantum correlation ; HMBC ; heteronuclear multiple bon

刊名：Fitoterapia

出版年：2016

7.Antithrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn. leaves in busulfan induced thrombocytopenic Wistar rats

作者：Vishwanath Zunjar^a ; Ranjeet Prasad Dash^b ; Mehul Jivrajani^b ; Bhavna Trivedi^a ; ^{trivedibhavna@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Manish Nivsarkar^b ; ^{manishnivsarkar@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ITP ; Idiopathic Thrombocytopenic Purpura ; CPL ; Carica papaya Linn. Leaves ; MRM ; Multiple Reaction Monitoring ; GLP ; Good Laboratory Practice ; CPCSEA ; Committee for the Purpose of Control and Supervision of Experiments on Animals ; IS ; Internal Standard ; LLOD ; Lower Limit of Detection ; LLOQ ; Lower Limit of Quantitation ; % RE ; Percentage Relative Error ; % CV ; Percentage Coefficient of Variation ; SEM ; Standard Error of Mean ; ICH ; International Conference on Harmonization ; API ; Atmospheric Pressure Io

刊名：Journal of Ethnopharmacology

出版年：2016

8.ECG telemetry in conscious guinea pigs

作者：Sabine Ruppert^a ; Thomas Vormberge^a ; Bernd-Wolfgang Igl^b ; Michael Hoffmann^a ; ^{michael.hoffmann@bayer.com" class="auth_mail" title="E-mail the corresponding author}

关键词：3Rs ; replacement ; refinement and reduction ; ECG ; electrocardiogram ; ICH ; international conference on harmonization ; NCE ; new chemical entity ; NHP ; non-human primate ; VAP ; venous access port

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

9.Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development

作者：P. Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; C. Regan ; K. Fitzgerald ; P. Gerenser ; J. Travis ; S. Wang ; P. Fanelli ; F. Sannajust

关键词：ANES GP ; anesthetized guinea pig ; AUC ; area under the curve ; CAVB ; complete atrioventricular blockade ; Cmax ; maximal plasmatic concentration ; ECG ; electrocardiogram ; EMw ; electromechanical window ; EMw-10 ; ; &minus ; ; 10% shortening of the EMw ; GP ; guinea pig ; FDA ; Food and Drug Administration ; hERG ; human Ether-a-go-go Related Gene ; HR ; heart rate ; ICH ; International Conference on Harmonization ; IKr ; rapidly-activating delayed rectifier potassium current ; LVP ; left ventricular pressure ; N

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

10.Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery

作者：Pedro Fonte^a ; ^b ; ^{pedrofonte86@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Salette Reis^a ; Bruno Sarmento^b ; ^c ; ^d ; ^{bruno.sarmento@ineb.up.pt" class="auth_mail" title="E-mail the corresponding author}

关键词：AFM ; atomic force microscopy ; BSA ; bovine serum albumin ; CD ; circular dichroism ; Cg&prime ; maximal concentration of the cryoconcentrated solution ; DSC ; differential scanning calorimetry ; ESCA ; electron spectroscopy for chemical analysis ; ESEM ; environmental scanning electron microscopy ; FTIR ; Fourier-transform infrared spectroscopy ; HPLC ; high performance liquid chromatography ; HPC ; hydroxypropyl cellulose ; HPβCD ; hydroxypropyl-β-cyclodextrin ; ICH ; International Conference on Harmonization ; LDH

刊名：Journal of Controlled Release

出版年：2016

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