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Elsevier电子期刊(13)

在“Elsevier电子期刊”中，命中：13条，耗时：0.0589714 秒

在所有数据库中总计命中：14条

1.Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates

作者：Taeko Kubo ; DVM ; PhD^a ; ^b ; ^c ; ^{taeko-kubo@ds-pharma.co.jp} ; ^{taekok2016@gmail.com} ; Takashi Ashihara ; MD ; PhD^b ; Tadashi Tsubouchi ; PhD^a ; Minoru Horie ; MD ; PhD^b

关键词：AP ; action potential ; APD ; action potential duration ; APD30 ; APD at 30% repolarization ; APD90 ; APD at 90% repolarization ; APD30&ndash ; 90 ; APD90&ndash ; APD30 ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CiPA ; Comprehensive in vitro Proarrhythmia Assay ; CV ; conduction velocity ; EAD ; early afterdepolarization ; ECG ; electrocardiogram ; Endo ; endocardial ; Epi ; epicardial ; FH ; failing heart ; ICH ; International Conference of Harmonization ; IQ-CSRC ; Innovation and Quality in Pharmaceutical Deve

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

关键词：APD ; action potential duration ; AERS ; adverse event reporting system ; CiPA ; Comprehensive in Vitro Proarrhythmia Assay ; EAD ; early after depolarizations ; ECG ; electrocardiogram ; HESI ; Health and Environmental Sciences Institute ; HT ; high throughput ; hSC-CM ; human cardiac stem cell derived cardiomyocyte ; hERG or IKr ; human ether-à ; -go-go related gene ; ISWG ; In Silico Working Group ; ICWG ; Ion Channel Working Group ; ICH ; International Conference on Harmonisation ; JiCSA ; Japan iPS Cardiac Safe

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

3.Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Jean-Michel Guillon^b ; Veronique Ballet^b ; Mike Clements^c ; Jean-Fré ; dé ; ric Gerbeau^d ; Henry Holzgrefe^e

关键词：Comprehensive in vitro Proarrhythmia Assay (CiPA) ; Field potential data sampling and analysis ; Induced pluripotent cell cardiomyocytes (hiPSC-CMs) ; Multi electrode array (MEA) ; Patch clamp technologies ; Pending issues and solutions ; Validation ; Voltage sensitive dye (VSD)

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

4.An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

作者：William J. Crumb Jr.^a ; ^{w.crumb@cytocentrics.com" class="auth_mail" title="E-mail the corresponding author} ; Jose Vicente^b ; Lars Johannesen^b ; David G. Strauss^b

关键词：CiPA ; Electrophysiology ; Ion channels ; Manual patch clamp ; Torsade de pointes

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

5.Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging

作者：Graham T. Dempsey^a ; Khuram W. Chaudhary^b ; ^{khuram.w.chaudhary@gsk.com" class="auth_mail" title="E-mail the corresponding author} ; Nicholas Atwater^a ; Cuong Nguyen^a ; Barry S. Brown^b ; John D. McNeish^c ; Adam E. Cohen^d ; ^e ; ^f ; Joel M. Kralj^a

关键词：CiPA ; Comprehensive in vitro Proarrhythmia Assay ; TdP ; Torsades de Pointes ; AP ; action potential ; CT ; Ca2 ; + transient ; hiPSC ; human induced pluripotent stem cell ; CM ; cardiomyocyte ; CaViar ; Ca2 ; + and voltage indicator ; CheRiff ; channelrhodopsin variant ; EAD ; early after depolarization ; ECG ; electrocardiogram ; hERG ; human Ether-à ; -go-go-Related Gene ; MEA ; multi-electrode array ; Arch ; Archaerhodopsin ; VSD ; voltage sensitive dye

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

6.The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Henry Holzgrefe^b ; Mike Clements^c

关键词：AP ; cardiac action potential ; CiPA ; comprehensive in vitro proarrhythmia assay ; CSRC ; Cardiac Safety Research Consortium ; Cmax ; maximal plasma concentration ; CTWG ; clinical translational working group ; DRest ; rate-normalized Tpeak ; &minus ; ; Tend ; = ; Tpe interval ; ECG ; electrocardiogram ; E-R ; exposure-response ; FDA ; Food and Drug Administration ; FIH ; first-in-humans ; hERG ; human ether-à ; -go-go-related gene ; hiPSC-CMs ; human induced pluripotent stem cell derived cardiomyocyte

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

7.CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability-

作者：Yumiko Nozaki^a ; Yayoi Honda^a ; Hitoshi Watanabe^a ; Shota Saiki^b ; ^g ; ¹ ; Kiyotaka Koyabu^b ; Tetsuji Itoh^b ; Chiho Nagasawa^c ; ^g ; ¹ ; Chiaki Nakamori^c ; Chiaki Nakayama^c ; Hiroshi Iwasaki^c ; Shinobu Suzuki^d ; ^g ; ¹ ; Ikumi Washio^d ; Etsushi Takahashi^e ; ^g ; ¹ ; Kaori Miyamoto^e ; Atsuhiro Yamanishi^f ; ^g ; ¹ ; Hiroko Endo^f ; Junko Shinozaki^f ; Hisashi Nogawa^f ; Takeshi Kunimatsu^a ; ^g ; ^h ; ¹ ; ^{takeshi-kunimatsu@ds-pharma.co.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Consortium for drug safety assessment using human iPS cells (CSAHi) ; Comprehensive in vitro Proarrthythmia assay (CiPA) ; Inter-facility variability ; Multi electrode array (MEA) ; Human iPS cells-derived cardiomyocytes (hiPS-CMs) ; Early after depolarization (EAD) or triggered activity (TA)

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

8.Human iPSC-derived Cor.4U cardiomyocytes as a predictive tool for different comprehensive in vitro proarrhythmia assay endpoints

作者：Ralf Kettenhofen^a ; ; Anika Duenbostell^a ; Greg Luerman^b ; Ping Li^c ; Yimei Yue^c ; Jared Bronson^c ; Hirofumi Horai^d ; Jean Marc D'Angelo^e ; Thomas Niedereichholz^f ; John Ken Gibson^a

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

9.A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel

作者：Zhihua Li ; ^{Zhihua.li@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Sara Dutta ; Jiansong Sheng ; Phu N. Tran ; Wendy Wu ; Thomas Colatsky

关键词：CiPA ; hERG ; Kv11.1 ; Markov model ; Methods ; Temperature

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

10.Safety pharmacology studies using EFP and impedance

作者：Alison Obergrussberger ; ^{ali@nanion.de" class="auth_mail" title="E-mail the corresponding author} ; Krisztina Juhasz ; Ulrich Thomas ; Sonja Stö ; lzle-Feix ; Nadine Becker ; Leo Dö ; rr ; Matthias Beckler ; Corina Bot ; Michael George ; Niels Fertig

关键词：CardioExcyte 96 ; Dofetilide ; E4031 ; EAD-like ; Extracellular field potential ; Impedance ; Isoproterenol ; Nifedipine ; Pentamidine ; Safety pharmacology

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

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