作者：Anita R. Iskandar^a ; ¹ ; ^{Anita.Iskandar@pmi.com} ; Carole Mathis^a ; ¹ ; ^{Carole.Mathis@pmi.com} ; Walter K. Schlage^b ; ^{WK.Schlage@t-online.de} ; Stefan Frentzel^a ; ^{Stefan.Frentzel@pmi.com} ; Patrice Leroy^a ; ^{Patrice.Leroy@pmi.com} ; Yang Xiang^a ; ^{Yang.Xiang@pmi.com} ; Alain Sewer^a ; ^{Alain.Sewer@pmi.com} ; Shoaib Majeed^a ; ^{Shoaib.Majeed@pmi.com} ; Laura Ortega-Torres^a ; ^{Laura.OrtegaTorres@pmi.com} ; Stephanie Johne^a ; ^{Stephanie.Johne@pmi.com} ; Emmanuel Guedj^a ; ^{Emmanuel.Guedj@pmi.com} ; Keyur Trivedi^a ; ^{Keyur.Trivedi@pmi.com} ; Gilles Kratzer^a ; ^{Gilles.Kratzer@gmail.com} ; Celine Merg^a ; ^{Celine.Merg@pmi.com} ; Ashraf Elamin^a ; ^{Ashraf.Elamin@pmi.com} ; Florian Martin^a ; ^{Florian.Martin@pmi.com} ; Nikolai V. Ivanov^a ; ^{Nikolai.Ivanov@pmi.com} ; Manuel C. Peitsch^a ; ^{Manuel.Peitsch@pmi.com} ; Julia Hoeng^a ; ^{Julia.Hoeng@pmi.com}

关键词：3D ; Three-dimensional ; AK ; Adenylate kinase ; BIF ; Biological impact factor ; CBF ; Ciliary beating frequency ; CCL ; Chemokine (C-C motif) ligand ; CFA ; Cell fate ; CPR ; Cell proliferation ; CS ; Cigarette smoke ; CST ; Cell stress ; CXCL ; Chemokine (C-X-C motif) ligand ; DEG ; Differentially expressed gene ; EGF ; Epidermal growth factor ; FDR ; False discovery rate ; FFT ; Fast Fourier transformation ; H&E ; Hematoxylin and eosin ; IL ; Interleukin ; IPN ; Inflammatory process networks ; MiRNA ; microRNA ; MMP ; Matrix me

刊名：Toxicology in Vitro

出版年：2017

作者：Sandro Steiner ; PhD ; ^{Sandro.Steiner@pmi.com} ; Shoaib Majeed ; MSc ; Gilles Kratzer ; MSc ; Julia Hoeng ; PhD ; Stefan Frentzel ; PhD

关键词：CMAG ; condensation monodisperse aerosol generator ; DSF ; disodium fluorescein ; VC24/48 ; Vitrocell® ; 24/48 aerosol exposure system ; PBS ; phosphate buffered saline ; PM ; particulate matter ; GVP ; gas-vapor phase ; APS ; aerodynamic particle sizer ; e-cigarettes ; electronic cigarettes ; GSD ; geometric standard deviation ; CFP ; cambridge filter pad ; CV ; coefficient of variation ; ULOQ ; upper limit of quantification ; LLOQ ; lower limit of quantification

刊名：Toxicology in Vitro

出版年：2017

作者：Carine Poussin ; ^{Carine.Poussin@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Alexandra Laurent ; Manuel C. Peitsch ; Julia Hoeng ; Hector De Leon

关键词：CS ; cigarette smoke ; FDR ; false discovery rate ; HCAECs ; human coronary artery endothelial cells ; I ; D ; and FD ; indirect ; direct and fresh direct ; respectively ; ICAM-1 ; intercellular adhesion molecule 1 ; MM6 ; Mono Mac 6 ; MRTP ; modified risk tobacco product ; NPA ; network perturbation amplitude ; (R)BIF ; (Relative) biological impact factor ; SELE ; E-selectin ; SM ; starvation medium ; TACE ; tumor necrosis factor-α-converting enzyme ; THS2.2 ; Tobacco Heating System 2.2 ; TNFα ; tumor necrosis factor-alpha

刊名：Toxicology

出版年：2016

作者：Ulrike Kogel^a ; ¹ ; Bjoern Titz^a ; ¹ ; Walter K. Schlage^b ; Catherine Nury^a ; Florian Martin^a ; Alberto Oviedo^c ; Stefan Lebrun^a ; Ashraf Elamin^a ; Emmanuel Guedj^a ; Keyur Trivedi^a ; Nikolai V. Ivanov^a ; Patrick Vanscheeuwijck^a ; Manuel C. Peitsch^a ; Julia Hoeng^a ; ^{julia.hoeng@pmi.com}

关键词：Modified risk tobacco product ; Systems toxicology ; Transcriptomics ; Proteomics ; Lipidomics ; Subchronic inhalation toxicity

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Florian Martin ; Marja Talikka ; Nikolai V. Ivanov ; Christelle Haziza ; Julia Hoeng ; ^{Hoeng@pmi.com} ; Manuel C. Peitsch

关键词：Smoking ; Blood ; Exposure response ; Gene expression signature ; Novel tobacco heating system ; MRTP

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Maurice R. Smith ; ^{Maurice.Smith@pmi.com} ; Bruce Clark ; Frank Lü ; dicke ; Jean-Pierre Schaller ; Patrick Vanscheeuwijck ; Julia Hoeng ; Manuel C. Peitsch

关键词：Tobacco harm reduction ; Heat-not-burn ; Modified risk tobacco product ; Scientific assessment approach

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Marco van der Toorn ; ¹ ; ^{Marco.vanderToorn@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Stefan Frentzel¹ ; ^{Stefan.Frentzel@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Hector De Leon ^{hdeleon68@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Didier Goedertier ^{Didier.Goedertier@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Manuel C. Peitsch ^{Manuel.Peitsch@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Julia Hoeng ^{Julia.Hoeng@pmi.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Transendothelial migration ; THP-1 cells ; Endothelial cells ; Atherosclerosis ; Modified risk tobacco product ; Tobacco-heating system

刊名：Food and Chemical Toxicology

出版年：2015

作者：Bjoern Titz ; ¹ ; ^{bjorn.titz@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Alain Sewer¹ ; Thomas Schneider¹ ; Ashraf Elamin¹ ; Florian Martin¹ ; Sophie Dijon ; Karsta Luettich ; Emmanuel Guedj ; Gregory Vuillaume ; Nikolai V. Ivanov ; Michael J. Peck ; Nveed I. Chaudhary ; Julia Hoeng ; Manuel C. Peitsch

关键词：COPD ; Smoking ; Sputum ; Systems toxicology ; Quantitative proteomics

刊名：Journal of Proteomics

出版年：2015

作者：Ulrike Kogel^a ; ^b ; ^{ulrike.kogel@pmi.com" class="auth_mail} ; Walter K. Schlage^a ; ^b ; ^{walter.schlage@contracted.pmi.com" class="auth_mail} ; Florian Martin^b ; ^{florian.martin@pmi.com" class="auth_mail} ; Yang Xiang^b ; ^{yang.xiang@pmi.com" class="auth_mail} ; Sam Ansari^a ; ^b ; ^{sam.ansari@pmi.com" class="auth_mail} ; Patrice Leroy^b ; ^{patrice.leroy@pmi.com" class="auth_mail} ; Patrick Vanscheeuwijck^a ; ^b ; ^c ; ^{patrick.vanscheeuwijck@pmi.com" class="auth_mail} ; Stephan Gebel^a ; ¹ ; ^{stephan.gebel@uni.lu" class="auth_mail} ; Ansgar Buettner^a ; ² ; ^{a.buettner@histovia.com" class="auth_mail} ; Christoph Wyss^b ; ^{christoph.wyss@pmi.com" class="auth_mail} ; Marco Esposito^b ; ^{marco.esposito@pmi.com" class="auth_mail} ; Julia Hoeng^b ; ^{julia.hoeng@pmi.com" class="auth_mail} ; Manuel C. Peitsch^b ; ^{manuel.peitsch@pmi.com" class="auth_mail}

关键词：AAALAC ; Association for Assessment and Accreditation of Laboratory Animal Care International ; BAL ; bronchoalveolar lavage ; BALF ; bronchoalveolar lavage fluid ; BIF ; biological impact factor ; CAM ; cell adhesion molecule ; COHb ; carboxyhemoglobin ; DEG ; differentially expressed genes ; EGAFS ; ethanol glycerol acetic acid formaldehyde saline ; FC ; fold-change ; FDA ; Food and Drug Administration ; FDR ; false discovery rate ; GC ; gas chromatography ; GCRMA ; GC-Robust Microarray Analysis ; GJIC ; gap junction in

刊名：Food and Chemical Toxicology

出版年：June 2014

作者：Julia Hoeng ; Marja Talikka ; Florian Martin ; Alain Sewer ; Xiang Yang ; Anita Iskandar ; Walter K. Schlage ; Manuel C. Peitsch ; ^{manuel.peitsch@pmi.com" class="auth_mail}

刊名：Drug Discovery Today

出版年：February, 2014