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Elsevier电子期刊(45)

在“Elsevier电子期刊”中，命中：45条，耗时：0.0189817 秒

在所有数据库中总计命中：47条

1.Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

作者：Stefan A. Mann^a ; ^b ; ¹ ; Mohammad Imtiaz^a ; Annika Winbo^c ; ² ; Annika Rydberg^c ; Matthew D. Perry^a ; ^b ; Jean-Philippe Couderc^d ; Bronislava Polonsky^d ; Scott McNitt^d ; Wojciech Zareba^d ; Adam P. Hill^a ; ^b ; ^{a.hill@victorchang.edu.au} ; Jamie I. Vandenberg^a ; ^b ; ^{j.vandenberg@victorchang.edu.au}

关键词：LQTS ; long-QT syndrome ; VM ; ventricular myocyte ; APD ; Action potential duration ; IKr ; rapidly activating delayed rectifier current ; IKs ; slowly activating delayed rectifier current ; INaL ; late (persistent) sodium current ; ICaL ; L-type calcium current ; NCX ; Sodium-calcium exchanger ; NaK ; Sodium-potassium pump

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

2.The positive frequency-dependent electrophysiological effects of the I_Kur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

作者：John Ford ; PhD^* ; James Milnes ; PhD^* ; Said El Haou ; PhD^* ; Erich Wettwer ; PhD^&dagger ; ; Simone Loose ; MD^&dagger ; ; Klaus Matschke ; MD^&Dagger ; ; Benoit Tyl ; MD^§ ; ; Patrick Round ; MBBS^* ; Ursula Ravens ; MD^&dagger ; ; ^{ravens@rcs.urz.tu-dresden.de" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; ANOVA ; analysis of variance ; AP ; action potential ; APA ; action potential amplitude ; APD20 ; APD50 ; APD90 ; action potential duration at 20% ; 50% ; and 90% of repolarization ; cAF ; chronic atrial fibrillation ; DMSO ; dimethyl sulfoxide ; dV/dtmax ; maximum upstroke velocity ; ECG ; electrocardiogram/electrocardiographic ; ERP ; effective refractory period ; HR ; heart rate ; IKur ; ultra-rapidly activating delayed-rectifier potassium current ; pAF ; paroxysmal atrial fibrillation ; PLT20

刊名：Heart Rhythm

出版年：2016

3.Proteolytic cleavage in the S1-S2 linker of the Kv1.5 channel does not affect channel function

作者：Andrew Hogan-Cann ; Wentao Li ; Jun Guo ; Tonghua Yang ; Shetuan Zhang ; ^{shetuan.zhang@queensu.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：CHX ; Cycloheximide ; co-IP ; Co-immunoprecipitation ; hERG ; Human ether-a-go-go-related gene ; IKur ; The ultra-rapidly activating delayed rectifier potassium current ; PK ; Proteinase K

刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes

出版年：2016

4.Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development

作者：P. Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; C. Regan ; K. Fitzgerald ; P. Gerenser ; J. Travis ; S. Wang ; P. Fanelli ; F. Sannajust

关键词：ANES GP ; anesthetized guinea pig ; AUC ; area under the curve ; CAVB ; complete atrioventricular blockade ; Cmax ; maximal plasmatic concentration ; ECG ; electrocardiogram ; EMw ; electromechanical window ; EMw-10 ; ; &minus ; ; 10% shortening of the EMw ; GP ; guinea pig ; FDA ; Food and Drug Administration ; hERG ; human Ether-a-go-go Related Gene ; HR ; heart rate ; ICH ; International Conference on Harmonization ; IKr ; rapidly-activating delayed rectifier potassium current ; LVP ; left ventricular pressure ; N

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

5.Channeling your inner ear potassium: K⁺ channels in vestibular hair cells

作者：Frances L. Meredith^a ; Katherine J. Rennie^a ; ^b ; ^{katie.rennie@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：K+ conductance ; Type I hair cell ; Type II hair cell ; Calyx ; Crista ; Utricle ; Saccule

刊名：Hearing Research

出版年：2016

6.Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

作者：Takehito Kondo^a ; Ichiro Hisatome^b ; ^{hisatome@med.tottori-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shouichi Yoshimura^b ; Endang Mahati^b ; Tomomi Notsu^b ; Peili Li^b ; Kazuhiko Iitsuka^a ; Masaru Kato^a ; Kazuyoshi Ogura^a ; Junichiro Miake^a ; Takeshi Aiba^c ; Wataru Shimizu^d ; Yasutaka Kurata^e ; Shinji Sakata^f ; Naoe Nakasone^g ; Haruaki Ninomiya^g ; Akira Nakai^h ; Katsumi Higakiⁱ ; Yasushi Kawata^j ; Yasuaki Shirayoshi^b ; Akio Yoshida^b ; Kazuhiro Yamamoto^a

关键词：LQTS ; long QT syndrome ; HERG ; human-ether-a-go-go-related gene ; HS ; heat shock ; HSP ; heat shock protein ; HSF ; heat shock factor ; GGA ; geranyl geranyl acetone

刊名：Journal of Arrhythmia

出版年：2016

7.QT interval correction assessment in the anesthetized guinea pig

作者：Pierre Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Hillary K. Regan ; Kevin Fitzgerald ; Sylvain Bernasconi¹ ; Pamela Gerenser ; Jeffrey Travis ; Patrick Fanelli ; Frederick Sannajust ; Christopher P. Regan

关键词：ANES GP ; anesthetized guinea pig ; BP ; blood pressure ; BT ; body temperature ; GP ; guinea pig ; hERG ; human ether-a-go-go related gene ; IKr ; rapidly-activating delayed rectifier potassium current ; IKs ; slowly-activating delayed rectifier potassium current ; MAP ; mean arterial pressure ; NCE ; new chemical entity ; NBE ; new biological entity ; QTc ; heart rate corrected QT interval ; QTcb ; Bazett's heart rate QT corrected interval ; QTcf ; Fridericia's heart rate QT corrected interval ; QTcVdW ; Van de Water's

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2015

8.Transfection by eukaryotic expression vector pcDNA3-HERG inhibits the cultured neonatal rabbit ventricular myocyte hypertrophy induced by phenylephrine

作者：Yonghui Zhao ; Yu Xu ; Changcong Cui ; Yu Li ; Yanjun Zeng

关键词：Action potentials ; Calcium ; Myocytes ; Hypertrophy ; Rapidly activating delayed rectifier K+ current

刊名：Cardiovascular Pathology

出版年：2012

9.Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig

作者：P.-J. Guns ; D.M. Johnson ; E. Weltens ; J. Lissens

关键词：E-M window ; electro-mechanical window ; ICaL ; L-type calcium current ; IKr ; rapidly activating delayed rectifier potassium current ; IKs ; slowly activating delayed rectifier potassium current ; INa ; sodium current ; LQTS ; long QT syndrome ; QTcB ; the heart rate

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2012

10.Arsenic trioxide-induced hERG K⁺ channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression

作者：Ying Zhang^a ; ^b ; ¹ ; Zengxiang Dong^a ; ^b ; ¹ ; Liyan Jin^a ; Kaiping Zhang^a ; Xin Zhao^a ; Jia Fu^a ; Yan Gong^a ; Mingming Sun^a ; Baofeng Yang^a ; ^b ; Baoxin Li^a ; ^b ; ^{libx64@hotmail.com}

关键词：As2O3 ; Matrine ; Oxymatrine ; hERG ; Sp1

刊名：Biochemical Pharmacology

出版年：2013

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