搜索页_Idiosyncratic+Hepatotoxicity

设为首页

收藏本站

网站地图 | English | 公务邮箱

读者指南

学术客户端

NSTL服务站

科技查新

外文资源

Elsevier电子期刊(89)

在“Elsevier电子期刊”中，命中：89条，耗时：小于0.01 秒

在所有数据库中总计命中：134条

1.In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries

作者：Doshi Utkarsh ; Carol Loretz ; Albert P. Li ; ^{lialbert@invitroadmet.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Hepatotoxicity ; DILI ; Idiosyncratic hepatotoxicity ; Individual differences ; Risk factors ; P450 ; CYP3A4 ; Acetaminophen ; Cyclophosphamide ; Ketoconazole ; Tamoxifen ; Human hepatocytes

刊名：Chemico-Biological Interactions

出版年：2016

2.The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

关键词：FLU ; flutamide ; AhR ; aryl hydrocarbon receptor ; ARNT ; aryl hydrocarbon receptor nuclear translocator ; CYP ; cytochrome P450 ; TCDD ; 237 ; 8-tetrachlorodibenzo-p-dioxin ; 3-MC ; 3-methylcholanthrene ; ABCC4 ; ATP-binding cassette sub-family C member 4 ; MRP4 ; multidrug resistance-associated protein 4 ; PAS ; Per-ARNT-Sim ; DRE ; dioxin-responsive elements ; LBD ; ligand binding domain ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; ALP ; alkaline phosphatase ; PXR ; pregnane X receptor ; CAR ; con

刊名：Biochemical Pharmacology

出版年：2016

3.European medicinal and edible plants associated with subacute and chronic toxicity part II: Plants with hepato-, neuro-, nephro- and immunotoxic effects

作者：Luka Kristanc^a ; ^b ; ^{luka.kristanc@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Samo Kreft^c ; ^{Samo.Kreft@ffa.uni-lj.si" class="auth_mail" title="E-mail the corresponding author}

关键词：European plants ; Hepatotoxic ; Neurotoxic ; Nephrotoxic ; Immunosuppressive ; Thiamine depletion

刊名：Food and Chemical Toxicology

出版年：2016

4.Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity

作者：Patrizia Haegler^a ; ^b ; David Grü ; nig^a ; ^b ; Benjamin Berger^a ; ^b ; Stephan Krä ; henbü ; hl^a ; ^b ; ^c ; ^{kraehenbuehl@ubs.ch" class="auth_mail" title="E-mail the corresponding author} ; Jamal Bouitbir^a ; ^b ; ^c

关键词：螖蠄m ; mitochondrial membrane potential ; BSA ; bovine serum albumin ; Cbl ; cobalamin ; DMEM ; Dulbecco's Modified Eagle Medium ; DMSO ; dimethyl sulfoxide ; EGTA ; ethylene glycol tetraacetic acid ; FCCP ; carbonyl cyanide p-(trifluoromethoxyl)-phenyl-hydrazone ; HCCL ; hydroxy-cobalamin[c-lactam] ; HPLC ; high-performance liquid chromatography ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; MTT ; methylthiazolyldiphenyl-tetrazolium bromide ; MM-CoA ; methylmalonyl-CoA ; ROS ; reactive oxygen species ; SD

刊名：Toxicology

出版年：2015

5.Oxidative stress/reactive metabolite gene expression signature in rat liver detects idiosyncratic hepatotoxicants

作者：Angelique Leone ; Alex Nie ; J. Brandon Parker ; Sharmilee Sawant ; Leigh-Anne Piechta ; Michael F. Kelley ; ^{mkelley2@its.jnj.com" class="auth_mail} ; L. Mark Kao ; S. Jim Proctor ; Geert Verheyen ; Mark D. Johnson ; Peter G. Lord ; Michael K. McMillian

关键词：Idiosyncratic hepatotoxicity ; Oxidative stress ; Reactive metabolites ; Adverse drug reactions ; Drug induced liver injury ; DILI

刊名：Toxicology and Applied Pharmacology

出版年：15 March, 2014

6.Minimizing DILI risk in drug discovery — A screening tool for drug candidates

关键词：Hepatotoxicity ; Liver injury ; DILI assessment ; Reactive metabolites ; BSEP inhibition ; Cytotoxicity ; Mitochondrial toxicity

刊名：Toxicology in Vitro

出版年：2015

7.Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting

作者：Sarah Tischer¹ ; Robert J. Fontana² ; ^{rfontana@med.umich.edu" class="auth_mail}

关键词：ALT ; Alanine aminotransferase ; AST ; Aspartate aminotransferase ; AUC ; Area under the curve ; BOC ; Boceprevir ; BSEP ; Bile salt export pump ; Cmax ; Maximum concentration ; CNI ; Calcineurin inhibitors ; CYP ; Cytochrome P450 ; DAA ; Direct acting antivirals ; DDI ; Drug-drug interaction ; DILI ; Drug induced liver injury ; DILIN ; Drug induced liver injury network ; FCH ; Fibrosing cholestatic hepatitis ; HCV ; Hepatitis C virus ; HDS ; Herbal and dietary supplements ; LT ; Liver transplantation ; mTORi ; Mammalian target

刊名：Journal of Hepatology

出版年：April, 2014

8.Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset

作者：Robert J. Fontana¹ ; ^{rfontana@med.umich.edu" class="auth_mail" title="E-mail the corresponding author} ; Paul H. Hayashi² ; Jiezhun Gu³ ; K. Rajender Reddy⁴ ; Huiman Barnhart³ ; Paul B. Watkins² ; Jose Serrano⁵ ; William M. Lee⁶ ; Naga Chalasani⁷ ; Andrew Stolz⁸ ; Timothy Davern⁹ ; Jayant A. Talwakar¹⁰ ; on behalf of the DILIN Network

关键词：Hepatotoxicity ; Acute Liver Failure ; Transplantation ; Causality

刊名：Gastroenterology

出版年：2014

9.Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

作者：Mercedes Robles&ndash ; Diaz¹ ; ² ; M. Isabel Lucena¹ ; ² ; ^{lucena@uma.es" class="auth_mail" title="E-mail the corresponding author} ; Neil Kaplowitz³ ; Camilla Stephens¹ ; ² ; Inmaculada Medina&ndash ; Cá ; liz¹ ; ² ; Andres Gonzá ; lez&ndash ; Jimenez¹ ; Eugenia Ulzurrun¹ ; ² ; Ana F. Gonzalez¹ ; M. Carmen Fernandez⁴ ; Manuel Romero&ndash ; Gó ; mez² ; ⁵ ; Miguel Jimenez&ndash ; Perez⁶ ; Miguel Bruguera² ; ⁷ ; Martí ; n Prieto² ; ⁸ ; Fernando Bessone⁹ ; Nelia Hernandez¹⁰ ; Marco Arrese¹¹ ; Raú ; l J. Andrade¹ ; ² ; on Behalf of the Spanish DILI Registry

关键词：Idiosyncratic Hepatotoxicity ; Prognostic Risk Factor ; Prediction ; Progression

刊名：Gastroenterology

出版年：2014

10.Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice

作者：Adarsh Gandhi^a ; ¹ ; ^{adarsh.gandhi@nih.gov} ; Tao Guo^a ; ² ; ^{tguo4@jhu.edu} ; Pranav Shah^a ; ¹ ; Bhagavatula Moorthy^b ; Romi Ghose^a ; ^{rghose@uh.edu}

关键词：CPZ ; chlorpromazine ; IADRs ; idiosyncratic adverse drug reactions ; JNK ; c-Jun-N-terminal kinase ; LPS ; lipopolysaccharide ; LTA ; lipoteichoic acid ; TIRAP ; Toll-interleukin 1 receptor domain containing adaptor protein ; TLR ; Toll-like receptor ; TNF ; tumor necr

刊名：Toxicology and Applied Pharmacology

出版年：2013

按检索点细分(89)

题名(5)

关键词(12)

文摘(66)

按出版年细分(89)

2027年及以后(3)

2016年(3)

2015年(2)

2014年(2)

2013年(5)

2012年(5)

2011年(6)

2010年(5)

2009年(9)

2008年(4)

2007年(5)

2006年(4)

2005年(4)

2004年(7)

2003年(4)

2002年(6)

2001年(1)

2000年(5)

2000年及以前(9)

常见问题　|　交通位置　|　联系我们　|　OA远程办公

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700