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Elsevier电子期刊(232)

在“Elsevier电子期刊”中，命中：232条，耗时：小于0.01 秒

在所有数据库中总计命中：232条

1.Significance of integrated in silico transmural ventricular wedge preparation models of human non-failing and failing hearts for safety evaluation of drug candidates

作者：Taeko Kubo ; DVM ; PhD^a ; ^b ; ^c ; ^{taeko-kubo@ds-pharma.co.jp} ; ^{taekok2016@gmail.com} ; Takashi Ashihara ; MD ; PhD^b ; Tadashi Tsubouchi ; PhD^a ; Minoru Horie ; MD ; PhD^b

关键词：AP ; action potential ; APD ; action potential duration ; APD30 ; APD at 30% repolarization ; APD90 ; APD at 90% repolarization ; APD30&ndash ; 90 ; APD90&ndash ; APD30 ; [Ca2 ; +]i ; intracellular Ca2 ; + concentration ; CiPA ; Comprehensive in vitro Proarrhythmia Assay ; CV ; conduction velocity ; EAD ; early afterdepolarization ; ECG ; electrocardiogram ; Endo ; endocardial ; Epi ; epicardial ; FH ; failing heart ; ICH ; International Conference of Harmonization ; IQ-CSRC ; Innovation and Quality in Pharmaceutical Deve

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

关键词：APD ; action potential duration ; AERS ; adverse event reporting system ; CiPA ; Comprehensive in Vitro Proarrhythmia Assay ; EAD ; early after depolarizations ; ECG ; electrocardiogram ; HESI ; Health and Environmental Sciences Institute ; HT ; high throughput ; hSC-CM ; human cardiac stem cell derived cardiomyocyte ; hERG or IKr ; human ether-à ; -go-go related gene ; ISWG ; In Silico Working Group ; ICWG ; Ion Channel Working Group ; ICH ; International Conference on Harmonisation ; JiCSA ; Japan iPS Cardiac Safe

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

3.New in vitro model for proarrhythmia safety screening: I_Ks inhibition potentiates the QTc prolonging effect of I_Kr inhibitors in isolated guinea pig hearts

作者：Pé ; ter Kui^a ; ¹ ; Szabolcs Orosz^b ; ¹ ; Hedvig Taká ; cs^c ; Annamá ; ria Sarusi^a ; Norbert Csí ; k^d ; Ferenc Rá ; rosi^e ; ^f ; Csongor Csekő^b ; Andrá ; s Varró ; ^a ; ^g ; Julius Gy. Papp^a ; ^g ; Tamá ; s Forster^c ; Attila S. Farkas^c ; ² ; ^{farkasamed@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Andrá ; s Farkas^c ; ²

关键词：ECG ; Guinea pig hearts ; Langendorff perfusion ; Methods ; Proarrhythmia ; Rate corrected QT interval ; Repolarization reserve ; Safety screening ; Synergism ; Torsades de pointes

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

4.Assessment of drug-induced proarrhythmias due to pilsicainide in patients with atrial tachyarrhythmias

作者：Hideki Koike ; MD ; ^{th99co@gmail.com} ; Tadashi Fujino ; MD ; PhD ; Makiko Koike ; MD ; Shintaro Yao ; MD ; Masaya Shinohara ; MD ; Ken Kitahara ; MD ; PhD ; Toshio Kinoshita ; MD ; PhD ; Hitomi Yuzawa ; MD ; Takeya Suzuki ; MD ; PhD ; Hideyuki Sato ; MD ; Shunji Fukunaga ; MD ; Kenzaburo Kobayashi ; MD ; PhD ; Takanori Ikeda ; MD ; PhD ; FJCC

关键词：Pilsicainide ; Proarrhythmia ; Renal dysfunction ; QRS interval ; QTc interval

刊名：Journal of Arrhythmia

出版年：2016

5.Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

作者：Scott E. Wolkenberg^a ; ^{scott_wolkenberg@merck.com} ; M. Brad Nolt^a ; Mark T. Bilodeau^a ; B. Wesley Trotter^a ; Peter J. Manley^a ; Nathan R. Kett^a ; Kausik K. Nanda^a ; Zhicai Wu^a ; Matthew J. Cato^b ; Stefanie A. Kane^b ; Laszlo Kiss^b ; Robert H. Spencer^b ; Jixin Wang^b ; Joseph J. Lynch^c ; Christopher P. Regan^c ; Gary L. Stump^c ; Bing Li^d ; Rebecca White^d ; Suzie Yeh^d ; Christopher J. Dinsmore^a ; Craig W. Lindsley^a ; George D. Hartman^a

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity

作者：Barbara Wiśniowska¹ ; Sebastian Polak¹ ; ² ; ^{spolak@cm-uj.krakow.pl}

刊名：Drug Discovery Today

出版年：2017

7.Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Jean-Michel Guillon^b ; Veronique Ballet^b ; Mike Clements^c ; Jean-Fré ; dé ; ric Gerbeau^d ; Henry Holzgrefe^e

关键词：Comprehensive in vitro Proarrhythmia Assay (CiPA) ; Field potential data sampling and analysis ; Induced pluripotent cell cardiomyocytes (hiPSC-CMs) ; Multi electrode array (MEA) ; Patch clamp technologies ; Pending issues and solutions ; Validation ; Voltage sensitive dye (VSD)

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

8.Divergent electrophysiologic profile of fluconazole and voriconazole in an experimental whole-heart model of proarrhythmia

作者：Gerrit Frommeyer^a ; ^{gerrit.frommeyer@ukmuenster.de" class="auth_mail" title="E-mail the corresponding author} ; Christina Fischer^a ; Philipp S. Lange^a ; Patrick Leitz^a ; Michael Fehr^b ; Harilaos Bogossian^c ; Peter Milberg^a ; Lars Eckardt^a

关键词：Fluconazole ; Voriconazole ; Dispersion of repolarization ; Proarrhythmia ; Sudden cardiac death

刊名：European Journal of Pharmacology

出版年：2016

9.The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com" class="auth_mail" title="E-mail the corresponding author} ; Henry Holzgrefe^b ; Mike Clements^c

关键词：AP ; cardiac action potential ; CiPA ; comprehensive in vitro proarrhythmia assay ; CSRC ; Cardiac Safety Research Consortium ; Cmax ; maximal plasma concentration ; CTWG ; clinical translational working group ; DRest ; rate-normalized Tpeak ; &minus ; ; Tend ; = ; Tpe interval ; ECG ; electrocardiogram ; E-R ; exposure-response ; FDA ; Food and Drug Administration ; FIH ; first-in-humans ; hERG ; human ether-à ; -go-go-related gene ; hiPSC-CMs ; human induced pluripotent stem cell derived cardiomyocyte

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

10.An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

作者：William J. Crumb Jr.^a ; ^{w.crumb@cytocentrics.com" class="auth_mail" title="E-mail the corresponding author} ; Jose Vicente^b ; Lars Johannesen^b ; David G. Strauss^b

关键词：CiPA ; Electrophysiology ; Ion channels ; Manual patch clamp ; Torsade de pointes

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

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