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Elsevier电子期刊(126)

在“Elsevier电子期刊”中，命中：126条，耗时：小于0.01 秒

在所有数据库中总计命中：187条

1.Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility

作者：Duncan Hieu M. Dam¹ ; ² ; Xiao-Qi Wang¹ ; ² ; Sarah Sheu¹ ; Mahima Vijay¹ ; Desmond Shipp¹ ; Luke Miller¹ ; Amy S. Paller¹ ; ^{apaller@northwestern.edu}

关键词：AS ; antisense oligonucleotide ; GCS ; glucosylceramide synthase ; GCSI ; glucosylceramide synthase inhibitor ; GM3S ; ganglioside GM3 synthase ; IGF-1 ; insulin-like growth factor-1 ; IGF1R ; insulin-like growth factor-1 receptor ; IR ; insulin receptor ; M2D3 ; GM2/GD2 and GD3 synthases ; NHEK ; normal human epidermal keratinocyte ; shRNA ; short hairpin RNA ; siRNA ; small interfering RNA ; SNA ; spherical nucleic acid

刊名：Journal of Investigative Dermatology

出版年：2017

2.Cell membrane modulation as adjuvant in cancer therapy

作者：Sara Zalba ; ^{s.zalbaoteiza@erasmusmc.nl} ; Timo L.M. ten Hagen

关键词：HMG-CoA reductase ; 3-hydroxy-methylglutaryl CoA reductase ; Emodin ; 3-methyl-16 ; 8-trihydroxyanthraquinone ; CL ; Cardiolipin ; Cer ; ceramide ; Ch ; cholesterol ; DAG ; Diacylglycerol ; ER ; endoplasmic reticulum ; EGFR ; epidermal growth factor receptor ; EGCG ; epigallocatechin gallate ; FADD ; Fas-Associated protein with Death Domain ; So ; gel solid-ordered state ; GCS ; Glucosylceramide synthase ; IP3 ; inositol 14 ; 5-triphosphate ; IGF-1 ; insulin-like receptor ; Ld ; liquid-disordered state ; Lo ; liquid-ordered sta

刊名：Cancer Treatment Reviews

出版年：2017

3.Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme

作者：Naohiro Hashimoto¹ ; Ikiru Matsumoto¹ ; Hiromasa Takahashi ; Hitomi Ashikawa ; Hiroyuki Nakamura ; ^{nakahiro@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author} ; Toshihiko Murayama

关键词：Niemann-Pick disease type C ; Cholesterol ; Glucosylceramide synthase ; Sphingomyelin ; Vesicular trafficking

刊名：Neuropharmacology

出版年：2016

4.Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine

作者：Anees Rahman^a ; ^{anees@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author} ; Faisal Thayyullathil^a ; ^{t.faisal@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author} ; Siraj Pallichankandy^a ; ^{sirajpk@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author} ; Sehamuddin Galadari^a ; ^b ; ^{sehamuddin@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author}

关键词：4EBP1 ; eukaryotic translation initiation factor 4E-binding protein 1 ; aCDase ; acid ceramidase ; Akt ; Akt/protein kinase B ; aSMase ; acid sphingomyelinase ; CalA ; calyculin A ; CAPP ; ceramide activated protein phosphatase ; CDase ; ceramidase ; Cer ; ceramide ; Desip ; desipramine ; DMSO ; dimethyl sulfoxide ; FB1 ; Fumonisin B1 ; FBS ; fetal bovine serum ; GCS ; glucosylceramide synthase ; GSH ; glutathione ; GSK3β ; glycogen synthase kinase 3 beta ; H2O2 ; hydrogen peroxide ; OH&minus ; hydroxyl radical ; IAP ; inhibitor

刊名：Free Radical Biology and Medicine

出版年：2016

5.Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor

作者：Shuhong Guan^a ; Yuan Y. Liu^b ; Tingzan Yan^a ; Jun Zhou^a ; ^{mdzhoujun918@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Lung cancer ; Sphingosine kinase 2 (SphK2) ; ABC294640 ; Glucosylceramide synthase (GCS) ; Ceramide

刊名：Biochemical and Biophysical Research Communications

出版年：2016

6.Glucosylceramide synthase inhibition reduces α-synuclein pathology and improves cognition in murine models of synucleinopathy

作者：S. Pablo Sardi ; Catherine Viel ; Jennifer Clarke ; Christopher Treleaven ; Hyejung Park ; James Dodge ; John Marshall ; Mandy Cromwell ; John Leonard ; Bing Wang ; Seng H. Cheng ; Lamya Shihabuddin

刊名：Molecular Genetics and Metabolism

出版年：2016

7.Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains

作者：Masayuki Sugimoto^a ; ^b ; Yoichi Shimizu^c ; Takeshi Yoshioka^a ; Masato Wakabayashi^a ; Yukari Tanaka^d ; Kenichi Higashino^a ; Yoshito Numata^a ; Shota Sakai^e ; Akio Kihara^f ; Yasuyuki Igarashi^e ; Yuji Kuge^b ; ^c ; ^{kuge@ric.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：SM ; sphingomyelin ; SMS ; sphingomyelin synthase ; Cer ; ceramide ; CerS ; ceramide synthase ; LC/ESI-MS/MS ; liquid chromatography/electrospray ionization-tandem mass spectrometry ; IMS ; imaging mass spectrometry ; ISH ; in situ hybridization ; MALDI ; matrix-assisted laser desorption/ionization ; FTICR ; Fourier transform ion cyclotron resonance ; VLCFA ; very long-chain fatty acid ; HexCer ; hexosylceramide ; GlcCer ; glucosylceramide ; GalCer ; galactosylceramide ; LacCer ; lactosylceramide

刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids

出版年：2015

8.New oleyl glycoside as anti-cancer agent that targets on neutral sphingomyelinase

作者：Lorenzo Romero-Ramí ; rez^a ; ^{lromeroramirez@sescam.jccm.es" class="auth_mail" title="E-mail the corresponding author} ; Isabel Garcí ; a-Á ; lvarez^a ; ^b ; Josefina Casas^c ; M.Asunció ; n Barreda-Manso^a ; ^d ; Natalia Yanguas-Casá ; s^d ; Manuel Nieto-Sampedro^a ; ^d ; Alfonso Ferná ; ndez-Mayoralas^b ; ^{alfonso.mayoralas@csic.es" class="auth_mail" title="E-mail the corresponding author}

关键词：UPLC-MS ; ultra performance liquid chromatography-mass spectrometry ; NMR ; nuclear magnetic resonance ; MTT ; methylthiazol tetrazolium ; IC50 ; 50% inhibitory dose ; UPRE ; unfolding protein response element ; ERSE ; endoplasmic reticulum stress element ; Cer ; ceramide ; SMs ; phingomyelin ; GlcCer ; glucosylceramide ; GCS ; glucosylceramide synthase ; SMS ; sphingomyelin synthase ; XBP-1 ; X-box binding protein 1

刊名：Biochemical Pharmacology

出版年：2015

9.Carcinogenicity testing of eliglustat in mice and rats

作者：Rafif Dagher^a ; ¹ ; ^{rdagher@catabasis.com" class="auth_mail" title="E-mail the corresponding author} ; Malene Watzinger^b ; ² ; ^{malene.watzinger@glpg.com" class="auth_mail" title="E-mail the corresponding author} ; Guillaume Chevalier^b ; ^{guillaume.chevalier@fr.citoxlab.com" class="auth_mail" title="E-mail the corresponding author} ; Catherine Thirion-Delalande^b ; ^{catherine.thirion-delalande@fr.citoxlab.com" class="auth_mail" title="E-mail the corresponding author} ; Frederic Gervais^b ; ^{frederic.gervais@fr.citoxlab.com" class="auth_mail" title="E-mail the corresponding author} ; Roy Forster^b ; ^{roy.forster@fr.citoxlab.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Eliglustat ; Cerdelga ; Carcinogenicity ; Glucosylceramide synthase inhibitor ; Gaucher disease ; Lysosomal storage disease

刊名：Regulatory Toxicology and Pharmacology

出版年：2015

10.Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione

作者：Abo Bakr Abdel Shakor^a ; ^b ; ^{eltayeb702002@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; ; Mona Atia^a ; Ali Saleh Alshehri^b ; Andrzej Sobota^c ; Katarzyna Kwiatkowska^c ; ^{k.kwiatkowska@nencki.gov.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：GCS ; glucosylceramide synthase ; GSH ; glutathione ; NAC ; N-acetylcysteine ; nSMase ; neutral sphingomyelinase ; PMSF ; phenylmethylsulfonyl fluoride ; ROS ; reactive oxygen species ; SMS ; sphingomyelin synthase

刊名：Cellular Signalling

出版年：2015

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